To get to Portuguese Settlement, you can take the #18 Ujong Pasir bus from Melaka Bus Sentral and it only costs $1.30 or yo can take the brand new air con Panorama Bus.
The route will take you to Clock Tower, Shopping at Makota and to Portuguese Settlement.
Just tell the bus driver that you are going to Portuguese Settlement.
The main road you take is Bandar Hillir thru Ujong Pasir and there you go.
If you get lost, just ask—just ask.